Friday, November 25, 2005

Health news 11-25-05

Bestmint by Ortek: A Disruptive Technology For More Than Tooth Decay

You can't put stuff like this in a SciFi plot. No one would believe it when the dentist said "eat lots of this candy please". No fiction: Ortek, Inc. is planning production of a candy that is reported to be more effective than sodium fluoride at preventing tooth decay. The active ingredient is an amino acid commonly found in nuts and whole grains. Some plausible ourcomes from introduction of the Ortek "Basicmints", assuming widespread popularity, include: a gradual end to flouride drips at the public water supply; no more dental fluoride treatments for kids; the phoenix-like "anti-fluoridation" movement, which has periodicaly attracted support from either end of the political spectrum, derails; toothpaste market shares are tossed in the air and pasteless toothbrushing becomes fashionable; outlays for filings are reduced; and, the need for one of the remaining consumer uses of elemental mercury ...we're talking about amalgam production by dentists... is reduced. While press coverage seemed to infer the use of a "biotech" method in manufacture (whatever that means), details are unclear. The meta-story is much bigger than an ingredient list though. Brace yourself for many more such disruptive technologies that confound and confuse our world views.

http://tinyurl.com/by8op

and the basicmints wweb site:

http://tinyurl.com/92wdd


Small RNA Molecules Tackle Herpes

By Karen Ross
ScienceNOW Daily News
23 November 2005

Efforts to stop the spread of sexually transmitted diseases (STDs) often fail because people don't take precautions in the heat of the moment. In an encouraging new development, researchers have designed and tested a topical therapy in mice that prevents infection by one of the most prevalent STDs, genital herpes virus, for days after it is applied.




Problem of emerging infectious diseases likely to worsen

Editorial: A walk on the wild side – emerging wildlife diseases BMJ Volume 331, pp 1214-5

Emerging infectious diseases pose a global threat to human and animal health, and the problem is likely to worsen, warns an expert in this week's BMJ.
The recent emergence of diseases, such as AIDS, SARS and avian flu, have catapulted emerging infectious diseases to the top of the medical and political agendas, and have highlighted the importance of wildlife as reservoirs or vectors for disease, writes Dr Andrew Cunningham.
Of pathogens causing emerging infectious diseases, 75% are zoonotic (able to transmit from animals to humans), with wildlife being an increasingly important source.
But why are we now seeing an apparently rapid increase in the emergence of new zoonoses from wildlife?
One of the major drivers is closer human contact with wildlife, primarily caused by human encroachment into, and modification of, wildlife habitat. For example, Ebola virus outbreaks often are linked to hunting for "bushmeat" or to mining development, and the AIDS pandemic originated from human encroachment into African forests for food.
The rise in international trade and travel is also important. The emergence of West Nile virus in North America, and AIDS and SARS globally, for example, arose from such travel and trade.
This globalisation of people and products is difficult to control and is largely related to increasing air transportation. With world air travel expected to grow at about 5% a year for at least the next 20 years, the problem of emerging infectious diseases will continue to grow, he warns.
Emerging infectious diseases are not only a problem for human health but are a major threat to animal welfare and to species conservation. Some emerging infectious diseases also threaten domesticated species.
Through emerging infectious diseases, therefore, the medical, veterinary, and wildlife conservation professions, share a common agenda. The problem is not small, and tackling it will not be easy, but recognising a common problem is, at least, a start, he concludes.



Wednesday, November 23, 2005

Pediatric Medical Traumatic Stress Toolkit for Health Care Providers

This toolkit was produced by the Medical Traumatic Stress Working Group of the National Child Traumatic Stress Network to:


  • Raise awareness among health care providers about traumatic stress associated with pediatric medical events and medical treatment, as it may affect children and families.
  • Promote "trauma-informed practice" of pediatric health care in hospital settings across the continuum of care and in a variety of settings within the hospital - e.g., from emergency care, to the ICU, to specialized inpatient units, to general pediatrics.

This compendium of materials is designed for hospital-based health care providers (physicians, nurses, and other health care professionals.) The materials may also be of use to mental health professionals who work in health care settings. The materials provide:


  • An introduction to traumatic stress as it relates to children facing illness, injury, and other medical events.
  • Practical tips and tools for health care providers.
  • Handouts that can be given to parents that present evidence-based tips for helping their child cope.

Health news 11-23-05

C.D.C. Proposes New Rules in Effort to Prevent Disease Outbreak
Published: November 23, 2005

Federal officials yesterday proposed the first significant changes in quarantine rules in 25 years in an effort to broaden the definition of reportable illnesses, to centralize their reporting to the federal government and to require the airline and shipping industries to keep passenger manifests electronically for 60 days.

http://tinyurl.com/83anp



With Cancer, Treatment Is Only Part of the Picture

More than 10 million people in the United States are cancer survivors, and their numbers increase daily. Many are considered cured. Some are still in treatment and one day may - or may not - be counted among the cured. Others are living with advanced disease.But nearly all have similar needs:

•A need to know about and cope with the physical and emotional consequences of cancer and its treatment, including current challenges to quality of life and delayed health effects.

•A need to know when to worry and when not to worry about symptoms that could signal a recurrence or a new cancer.

•A need for reliable information and assistance on matters like diet, exercise and smoking cessation that may improve survival chances.

•A need to deal with employment and insurance problems related to their medical histories.

Such needs inspired a panel of the National Academies this month to call for major improvements in follow-up care for cancer patients, who are too often left to struggle on their own with serious cancer-related matters.

http://tinyurl.com/ddkh6


Survey finds toys dangerous to kids

Makers accused of disregarding safety

WASHINGTON -- Though decades of effort have made toys safer, children still choke on balloons, get strangled by yo-yo water balls and suffer hearing damage from loud playthings, a watchdog group warned Tuesday in its annual toy safety survey.
The U.S. Public Interest Research Group's 20th survey noted that the Consumer Product Safety Commission reported the deaths of 16 children in toy-related incidents last year, along with another 210,000 emergency room visits. Choking on small parts, balls and balloons remains a leading cause of death and injury in kids younger than 15.



Breast-Feeding May Lower Mom's Risk of Diabetes 
By Serena Gordon
HealthDay Reporter 

TUESDAY, Nov. 22 (HealthDay News) -- Breast-feeding your baby can cut your risk of developing type 2 diabetes, new research shows.  "We found that breast-feeding is really good for mothers. Each year she breast-feeds cuts the risk of type 2 diabetes by 15 percent," said study author, Dr. Alison Stuebe, a clinical fellow in maternal fetal medicine at Brigham and Women's Hospital, and an instructor at Harvard Medical School in Boston.

http://tinyurl.com/afvwd



When Parasites Go Pop!

By Meagan White
ScienceNOW Daily News
22 November 2005

Lathering up with topical creams before each swim may no longer be necessary to prevent schistosomiasis, a water-borne parasitic infection that kills an estimated 800,000 people a year. A mix of red cedarwood oil and surfactant--a compound that makes oil spread evenly on the water surface--can kill schistosome larvae by making them swell and explode, according to a new study.
Schistosomiasis, also known as bilharzia, infects 200 million people in Africa, the Middle East, and Asia. Repeated infections can cause severe and eventually deadly damage to the liver, intestines, lungs, bladder, and the brain.



Mortality among very low-birthweight infants higher at minority-serving hospitals


BACKGROUND: Neonatal mortality rates--that is, mortality in the first 28 days--in the United States fell significantly between 1940 and 2000 from 28.8 deaths per live birth to 4.6 deaths. Yet ethnic and racial disparities have persisted or increased during that time. Deaths among very low-birthweight infants (VLBW) account for more than half the infant deaths in the United States. The researchers sought to determine whether there is a correlation between mortality among VLBW infants and quality of care. The research was based on data from 74,000 infants at 332 hospitals across the nation.

FINDINGS: The researchers found that infant mortality for black and white infants born at minority-serving hospitals, defined as hospitals where 35 percent of VLBW infants are black, was significantly higher than for black and white infants born at hospitals where fewer than 15 percent of these infants are black. These findings suggest that minority-serving hospitals provide lower quality care to VLBW infants than do other hospitals.

IMPACT: "There's a known disparity between blacks and whites in infant mortality," said Dr. Leo Morales, associate professor of general internal medicine and health services research at the David Geffen School of Medicine at UCLA, and the lead researcher. "This study points to a possible explanation for that disparity--namely that hospitals where the majority of black infants are born do not provide the same quality of care as hospitals where the majority of White infants are born." The next step is to investigate the reasons for the disparity, such as financial status, physician and nursing staffing and other hospital characteristics.

AUTHORS: Other researchers on this study in addition to Morales are Douglas Staiger of Dartmouth College and the National Bureau of Economic Research; Jeffrey D. Horbar of the University of Vermont and the Vermont Oxford Network; Joseph Carpenter, Vermont Oxford Network; Michael Kenny of the University of Vermont; Jeffrey Geppert, National Bureau of Economic Research, and Jeannette Rogowski, RAND Corp.

http://tinyurl.com/983zv



Tuesday, November 22, 2005

Health news 11-22-05

Lifelong benefits of cuddling your baby
by JULIE WHELDON, Daily Mail
09:39am 22nd November 2005
It may come as no surprise to parents, but cuddling your baby provides them with social benefits for years afterwards, according to scientists.
They found a clear link between love and attention in the early years and healthy emotional responses in later life.
Children who have been deprived of physical contact as babies have lower levels of social-bonding hormones, the researchers found.

Even if they are then smothered with love as toddlers, it can be very difficult to repair the damage.  The research, published in the journal Proceedings of the National Academy of Sciences, looked at hormones called oxytocin and arginine vasopressin.  Both play a role in response to stress and social bonding, with levels typically rising after the subject has been comforted with human contact.  The scientists took 18 children aged around four and a half who had been born in orphanages and therefore missed out on the level of physical contact they might have had from a mother and father.

http://tinyurl.com/948gw

Childhood Scars That Never Heal

By Constance Holden
ScienceNOW Daily News
21 November 2005

Researchers have long suspected that abuse or neglect early in life can permanently alter people's brains, making them more prone to anxiety and depression, less able to handle stress, or even incapable of forming strong attachments with others. There has been little molecular evidence to back this up, however. Now a group reports that children who started life as neglected orphans show long-term deficiencies in hormones related to social attachment.
Hormones play an important role in our interactions with others. Oxytocin levels increase during warm physical interactions with a familiar person, and vasopressin is related to recognizing familiar people. Studying these hormones has proven difficult in small children, however, because they have to be obtained via blood samples or spinal taps.



Daycare illness guidelines exist, but largely unknown

A new Cincinnati Children's Hospital Medical Center study shows that parents, pediatricians and child care providers are equally unknowledgeable about guidelines that recommend whether children should be excluded from child care due to particular illnesses.
As a result, children may be excluded for harmless conditions that do not meet national criteria, such as colds and allergic conjunctivitis, while being allowed to return to child care for some conditions that warrant staying home, such as uncontrolled coughing or persistent diarrhea, according to Kristen Copeland, M.D., a pediatrician at Cincinnati Children's and lead author of the study.
The study, published in the November-December issue of Ambulatory Pediatrics, found that child care providers, parents and pediatricians knew guideline recommendations for 12 common childhood ailments only 60 percent of the time.
"Inappropriate exclusions from child care can have a significant economic impact," says Dr. Copeland. "When their child attending child care becomes ill, parents have limited options. It's easy to see how exclusion can become a contentious issue between parents who may think child care providers are inconsistent and unreasonable in their application of guidelines and those child care providers who resent some parents' attempts to subvert the guidelines."



SLU research on teen moms refutes conventional wisdom: Early motherhood may not ruin their lives

Nurses can play pivotal role in helping young families succeed

ST. LOUIS -- A new Saint Louis University study rebuts the assumption that all teenagers who have babies face a future of dismal failure.  "Earlier studies exaggerated the long-term negative consequences associated with teenage mothering," says Lee SmithBattle, R.N., DNSc, professor of nursing at Saint Louis University Doisy College of Health Sciences and principal investigator of a qualitative study that analyzed the experiences of teen mothers a dozen years after they had given birth to their first child.  "This study and several others show that teen mothers fare better over time than our assumptions suggest," she says.  SmithBattle, who has been researching teen mothers for 17 years, found that early motherhood has not ruined their lives.  She has followed the lives of mothers and their families every four years, starting when their babies were less than a year old. For this article, SmithBattle analyzed interviews conducted when 11 moms were in their 30s to show how becoming a mom as a teen affected their lives. Her article appears in this month's issue of Western Journal of Nursing Research.




Multiple-birth babies, boys have higher risk of defects

GAINESVILLE, Fla. - Twins, triplets and other multiples have a nearly 50 percent greater chance of being born with birth defects, and boys tend to be more at risk than girls, according to two population-based studies conducted at the University of Florida.
UF researchers who studied all Florida births from 1996 through 2000 found multiples have a higher risk than babies born singly of developing 23 of 40 birth defects, such as spina bifida, according to results recently published online in the Maternal and Child Health Journal.
The same team of researchers, from UF's Maternal Child Health Education Research and Data Center, studied 4,768 pairs of opposite-sex twins and found that boys had a 29 percent higher risk for birth defects than girls. This could be because boys tend to develop at a slower pace, leaving a little more time for potential problems to arise, according to findings published this month in Birth Defects Research (Part A): Clinical and Molecular Teratology.  "In the past 20 years, multiple births have increased because of greater reliance on assistive reproductive technology, especially among women delaying childbirth until their 30s and 40s," said Yiwei Tang, M.D., an assistant professor of pediatrics and a lead researcher on both studies. "In offering these options to women, full disclosure of an increased risk of birth defects should be made."



ADHD medication might also treat hyperactivity symptoms in autism

Methylphenidate, a medication used to treat attention-deficit hyperactivity disorder (ADHD), may be effective in treating hyperactivity symptoms in children with autism and related pervasive developmental disorders, researchers report in the November Archives of General Psychiatry.
The study was conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network, a National Institute of Mental Health funded multi-site consortium dedicated to the development and testing of treatments for children with pervasive developmental disorders such as autism. The Yale team is directed by Lawrence Scahill, associate professor of nursing and child psychiatry at Yale.
"This study shows that methylphenidate is an effective medication for children with pervasive developmental disorder (PDD) accompanied by increased hyperactivity," said Scahill. "However, the percentage of children showing a positive response and the magnitude of benefit is lower than what we have come to expect in ADHD uncomplicated by PDD."



Periodontal therapy may reduce the incidence of preterm births and low birthweight infants

Study showed that women with gingivitis who received periodontal therapy before

CHICAGO – Pregnant women will want to include a periodontal evaluation as part of their prenatal care. That's because researchers found that periodontal treatment significantly reduced the risk of having a preterm birth or a low birthweight infant, according to a study published in the Journal of Periodontology.
"We found a significant association between gingivitis and preterm birth after adjusting for the major risk factors for preterm delivery, suggesting that gingivitis, the earliest form of periodontal disease, is an independent risk factor for preterm birth and low birthweight," said Dr. Néstor J. López, Professor of the University of Chile. "Periodontal therapy reduced preterm birth and low birthweight infant rates by 68 percent in women with pregnancy-associated gingivitis."
This is in concordance with two other intervention studies in which periodontal treatment reduced the incidence of preterm births and low birth weight infants between 71 percent and 84 percent in pregnant women with moderate to severe chronic periodontitis.
"Ideally, women should begin their pregnancy without periodontal infections, and they should be educated and motivated to maintain a high level of oral hygiene prior to and throughout pregnancy," said López. "If periodontal infection is diagnosed at any time during pregnancy, the treatment should be administered as soon as possible in order to reduce the risk of preterm birth and low birthweight."








Monday, November 21, 2005

health news for Nov 21

Do increased levels of testosterone play a role in Sudden Infant Death Syndrome?

Sudden Infant Death syndrome (SIDS) is the leading cause of unexpected death in infants ages one week to one year old. Although the number of SIDS related deaths has decreased due to greater public awareness regarding infants' sleep positions, the cause of SIDS remains unknown. However, a study in the November issue of The Journal of Pediatrics shows that elevated testosterone levels may put infants at greater risk for SIDS.

Michael Emery, PhD, from the University of Washington, and colleagues tested estrogen and testosterone levels in the blood serum of 127 infants who had died of SIDS and 42 infants who had died of other causes of unexpected infant death. They found that the testosterone levels in the male SIDS infants were 120% higher than in male non-SIDS infants and 50% higher in female SIDS infants than in female non-SIDS infants. Estrogen levels were not different among the SIDS and non-SIDS infants.
"These results may be important for better understanding of SIDS because the known relationship between testosterone and breathing during sleep provides a mechanism that potentially contributes to SIDS," says Dr. Emery. Previous studies have indicated that higher levels of testosterone may result in depressed breathing during sleep, which in turn may increase the risk of SIDS.



Twins' lower IQ levels than single-born children not down to social factors

The cognitive cost of being a twin: evidence from comparisons within families in the Aberdeen children of the 1950s cohort study, BMJ Online First

Social and economic circumstances do not explain why twins have significantly lower IQ in childhood than single-born children, according to a study in this week's BMJ.
Researchers studied 9,832 single-born children and 236 twins born in Aberdeen, Scotland between 1950 and 1956, using a previous child development survey as a base. They also gathered further information on mother's age at delivery, birth weight, at what stage of the child's gestation they were born, their father's occupational social class, and information on other siblings.
They found that at age seven, the average IQ score for twins was 5.3 points lower than that for single-born children of the same family, and 6.0 points lower at age nine.
The study also showed that taking into account factors such as the child's sex, mother's age, and number of older siblings made little difference to the IQ gap.
Despite advances in recent years in obstetric practice and neonatal care, the authors argue that the likely explanation is because some twins have a shorter length of time in the womb than other children and are prone to impaired fetal growth.




Researchers zero in on the possible cause of Kawasaki disease

In an important discovery in infectious disease research, a team of scientists from Northwestern University has identified a possible viral cause of Kawasaki disease, the most common cause of acquired heart disease in children in developed nations.
Since 1967 when Kawasaki disease was originally described, investigators have suspected an infectious cause, but, until now, none has been identified.
The research group was led by Anne H. Rowley, M.D., professor of pediatrics and of microbiology/immunology at Northwestern University Feinberg School of Medicine and Children's Memorial Hospital.
An article describing the new findings was published in the Nov. 15 issue of the Journal of Infectious Disease.



Childcare reduces stress levels for kids with working mums

Low job satisfaction in working mothers increases the stress levels of their children, but spending longer in childcare can help overcome these effects, new research has shown.

In a study involving more than 50 nursery school children, researchers found higher levels of the stress hormone cortisol in children whose mothers found their jobs less rewarding, or left them feeling emotionally exhausted, than those who reported more enjoyment from their jobs.

Levels of cortisol in the evening were more than double in these children.

Yet for women who have low job satisfaction, the research suggests that placing their children in childcare would help to significantly reduce the stress experienced by their children.

The researchers also found that children from families that were either highly expressive or reserved also exhibited higher than average cortisol levels.

http://tinyurl.com/afs5b




Thursday, November 17, 2005

health news

Scientists evaluate impact of preemptive malaria treatment for infants

Experts from the international consortium on IPTi present latest findings on a promising new approach for fighting malaria in children

Yaoundé, Cameroon (17 November 2005)--Administering malaria medicines preemptively to infants in malaria endemic regions has emerged as a potentially effective way to protect young children from the ravages of the disease. Children account for the majority of malaria deaths.
Leading scientists from an ambitious international consortium charged with evaluating the potential of Intermittent Preventive Treatment in Infants (IPTi) will explore the results of a recent clinical trial in Ghana and preliminary evidence from other IPTi research underway in Africa. IPTi has the potential to become a major tool for malaria control in Africa as it may be delivered at the time of routine childhood vaccination--through the Expanded Program on Immunization (EPI)--which increases the chance of long-term sustainability.


New study finds malaria could play key role in mother-to-child transmission of HIV in pregnancy

Yaoundé, Cameroon (17 November 2005)--Malaria infections boost production of a substance that might significantly increase HIV replication in the placenta. This interaction could explain why mother-to-child transmission (MTCT) of HIV in Yaoundé increases following a rainy season, according to new findings presented at this week's Fourth Multilateral Initiative on Malaria (MIM) Pan-African Malaria Conference.
Laboratory tests have revealed that biological substances known as "proinflammatory cytokines", such as TNF-alpha, which is found in high levels in placentas infected with malaria, could stimulate HIV replication in the placenta.
"Our research highlights the fact that placental malaria, through the placental cytokine network, could play an important role in mother-to-child HIV transmission in utero that has been underestimated so far," said Anfumbom Kfutwah of the Pasteur Center's virology laboratory. (Thursday, 3:10 p.m., Ebony Hall, Parallel Session 26, Presentation 169)
He said scientists have been investigating a possible link between malaria and in utero HIV infections since a study conducted in Yaoundé, Cameroon found that MTCTs peaked three months after the rains peaked. Seasonal rains are known to bring an increase in malaria infections by providing the ideal breeding environment for mosquitoes that carry the disease.


Research reveals likely connection between early-life stress and teenage mental health problems

Research to be presented Wednesday, Nov. 16, at the Society for Neuroscience Meeting in Washington, D.C.

WASHINGTON, D.C. – Research conducted at the Oregon National Primate Research Center at Oregon Health & Science University and at the University of Pittsburgh suggests a strong link between significant stress early in life and the increased incidence of mental health problems during adolescence. The research strengthens the case for proactive treatment or counseling of children who undergo a significant early-life stress. The research is being presented during the Society for Neuroscience meeting in Washington, D.C., Nov. 12-16. The meeting is one of the largest and most respected gatherings of neuroscientists in the world.
Both past research and human observation reveal that children who experience early-life stresses such as abuse, neglect, or loss of a parent have an increased risk of developing attachment disorders. Later in childhood, these same children show an increased incidence of manifesting some types of behavioral and emotional disorders, including attention deficit/hyperactivity disorder, conduct disorders, anxiety, depression, suicide, drug abuse and post-traumatic stress disorder. Both genetic factors and life experiences appear to play a role in the causes of these mental health disorders.


A fast diagnosis for bacterial meningitis

University of Sydney researchers at Westmead Millennium Institute develop an accurate and rapid method of diagnosing bacterial meningitis.

Several hundred serious cases of bacterial meningitis are diagnosed in Australians every year. Bacterial meningitis is a medical emergency that requires immediate diagnosis and treatment, however doctors have always faced difficulty in diagnosis, both in children and adults.
Professor Tania Sorrell and her team at Westmead Millennium Institute have discovered a quick and effective diagnostic for identifying bacterial meningitis using metabonomics.
Metabonomics is the study of the chemical composition of body fluids and tissues. All living organisms carry a unique metabolic fingerprint, and this can be identified using sophisticated techniques such as nuclear magnetic resonance (NMR) and mass spectrometry.
Researchers in this study compared the metabolic fingerprints of spinal fluid from patients who presented with meningitis-like symptoms at Westmead Hospital. They found that those with bacterial meningitis could be easily and accurately differentiated from those with non-infected fluid, and even from viral meningitis.
"When diagnosing bacterial brain infections, accuracy and speed are vitally important" says chief investigator Professor Tania Sorrell.
"Bacterial meningitis can be difficult to diagnose, particularly in young children, and this method will lead to faster and more targeted treatment meaning better outcomes."
Whilst this diagnostic is ready for the pathology lab, most hospitals do not yet possess the technology required. As technology advances however, and hospitals obtain more powerful equipment, the diagnosis and treatment of bacterial meningitis will become faster and more effective.

Wednesday, November 16, 2005

BIRD FLU NEWS

China Reports Three Human Bird-Flu Cases 
(AP) China confirmed its first two human cases of bird flu on the mainland Wednesday, including at least one fatality, as the government raced to vaccinate billions of chickens, ducks and other poultry in a massive effort to stop the spread of the virus.

The government suspected a third case of bird flu in a 12-year-old girl who died, but her body was cremated before it could be tested.

The Health Ministry confirmed cases in a poultry worker who died and a 9-year-old boy who fell ill but recovered, the official Xinhua News Agency said. It said the boy's 12-year-old sister, who died, was recorded as a suspected case.

Experts are especially worried about the potential for bird flu to spread and mutate in China because of its vast poultry flocks and their close contact with people. It also is a major migration route for wild fowl, which experts say might be spreading the virus.

China has reported 11 outbreaks in chickens and ducks in the past month nationwide, prompting authorities to destroy millions of birds in an effort to contain the virus. The government also announced an ambitious effort Tuesday to vaccinate all the country's more than 14 billion farm birds.



A protein may be key to hearing

Scientists believe they have discovered the protein responsible for converting sound into an electrical response the brain can understand and act upon.

"This is certainly one of the Holy Grails in the hearing world," said Peter Gillespie, a professor at Oregon Health & Sciences University in Portland. "Everyone is excited, but there is still a lot that needs to be done to prove that this is the right protein."

The finding of TRPA1 marks the end of a 25-year search, said lead investigator Jeffrey Holt, an assistant professor at the University of Virginia. He presented his findings this week at the Society for Neuroscience annual meeting in Washington, D.C.

About 16,000 hair cells lining the inner ear are responsible for registering sound and head movements and turning them into electrical signals.

Holt and colleagues discovered that hair cells develop late in the first trimester, and set out to find the genes that activate this development. That's when they found TRPA1. In the laboratory, they shut down TRPA1 and were able to stop hair cells from performing their job. The cells were no longer sensitive to sound.

They unraveled the structure of the protein and found that it looks like a doughnut. In the absence of sound, the hole in the doughnut stays closed. When sound strikes the hair cells, the hole pops open and lets in calcium and potassium, positively charged ions that result in an electrical signal.

Now, investigators are hoping to study patients with hearing loss to see if the TRPA1 gene is damaged, and/or whether the protein it makes is abnormal. They also discovered that a second protein called myosin amplifies sound in the inner ear. Myosin is critical in hearing a range of sounds.

Holt hopes these discoveries will lead to new ways to prevent or treat human deafness. One in 1,000 children is born deaf. They are now working on gene therapy to deliver into the inner ear the genes that make TRPA1 and myosin.

Todays health news

Antidepressants potentially misused in treating adolescents, Stanford study finds

STANFORD, Calif. - When the U.S. Food and Drug Administration declared in 2004 that certain antidepressants are linked to an increased risk of suicide in adolescents, there was surprisingly little data about how depression was being treated in young patients. Now new research from the Stanford University School of Medicine provides critical documentation of the potential misuse of these medications in the years leading up to the FDA's decision to issue the so-called "black-box" warnings.
The researchers found that, despite clinical guidelines calling for depressed adolescents to be treated with a combination of psychotherapy and medication, antidepressants began supplanting - rather than complementing - the role of mental health counseling between 1995 and 2002. And although only one antidepressant has been sanctioned for use in children, the study found that doctors were prescribing a variety of mood-altering medications for young patients.
The researchers hope their findings provide a benchmark for assessing how the 2004 decision affects depression treatment in children, while reinforcing that antidepressants can be a valuable treatment tool if used appropriately.



Caution: New Medicare drug plan may cause headaches

CHAMPAIGN, Ill. -- If many seniors are scratching their heads about the new Medicare prescription drug plan, so are the experts.
"A prescription for confusion" is how Richard L. Kaplan, a professor of law at the University of Illinois, characterizes the new drug benefit, whose enrollment period begins today for Americans aged 65 years and older.
Kaplan describes the plan as "fashioned like no other pharmaceutical coverage in the world."
For starters, the program, known as Medicare Part D, will be administered by private insurance companies rather than the Social Security Administration, which handles hospitalization and doctor's bills under current Medicare coverage, known as Parts A and B.
This shift means that seniors must choose between drug plans with widely differing premiums, deductibles, co-payments and covered drugs. In Kansas, for example, Medicare beneficiaries have to shop for insurance among 40 plans from insurers such as Aetna, Humana and UnitedHealth Group, which charge premiums from $9.48 a month to $67.88 a month.



Comic books shadow how we react to threats

In times of social danger and economic turmoil, many psychologists believe that people become more aggressive, more conventional, and less interested in feelings and emotions. A new study published in the latest issue of Political Psychology finds that comic book characters do these things as well. In times of higher threat, i.e. the events of 1979 which included the Iran hostage crisis, comic books contained more aggressive imagery, focused on male characters, and were less introspective. The authors reviewed comic books published between 1978 -1992 frame by frame to judge the amount of violence and conventionalism drawn, the number of women and minorities in speaking or subordinate roles, portrayal of wrongdoing by the authorities, and the amount of reflection (thought in balloons rather than dialogue). In general, the authors found that women spoke less and a significantly greater number of panels were devoted to aggression during high threat periods.
The authors reviewed eight Marvel comic books that are still published today. These titles included four titles that featured more conventional heroes that represent American virtues like U.S. patriotism (Captain America) and the everyman (Spider-Man). The other four heroes were less conventional with themes such as persecution by society (X-men) and a vigilante who lives in an "amoral urban hell" (Daredevil). When compared against their own sales, the unconventional titles sold more copies during the low-threat times compared to the high-threat times; whereas the conventional hero sales remained flat. "As an aspect of popular culture, comic books have always reflected the historical time period in which they were produced," author Bill Peterson explains.



Treatment has demonstrated improvement in physical function and kept joint damage from progressing

Enbrel plus Methotrexate: First treatment to demonstrate ability to inhibit radiographic progression of joint damage for three consecutive years

THOUSAND OAKS, Calif. and COLLEGEVILLE, Pa., November 13, 2005 – Amgen (NASDAQ: AMGN) and Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), today announced data from a long-term blinded study of anti-TNF agent in patients with rheumatoid arthritis (RA) demonstrated that more than three quarters of patients treated with Enbrel® (etanercept) plus methotrexate combination therapy experienced no progression of joint damage at three years. These new results from the TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study will be presented at the American College of Rheumatology's (ACR) Annual Scientific Meeting in San Diego, California.

http://tinyurl.com/cvsa8



Kidney failure, hypertension in children, topics of findings from nephrologists at Texas Children's Hospital

Two studies just released by physicians at Texas Children's Hospital are addressing new findings in patients with pediatric kidney failure, and on the growing prevalence of high blood pressure in children. The findings of both studies were released during a press conference at Renal Week 2005, the 38th annual conference of the American Society of Nephrology.

Dr. Stuart L. Goldstein, medical director of the Renal Dialysis Unit at Texas Children's Hospital, and associate professor of pediatrics, Baylor College of Medicine, and Dr. Daniel I. Feig, chief of the Pediatric Hypertension Clinic's at Texas Children's and Ben Taub General Hospital, and assistant professor of pediatrics, Baylor College of Medicine, were two of only five physicians nationwide to have their pediatric projects selected for the conference's pediatric briefing.

Dr. Goldstein's study "Mild Renal Insufficiency is Associated with Poor Outcome in Children with Acute Decompensated Heart Failure: Evidence for a Pediatric Syndrome" stems from a collaboration between the Renal and Cardiology departments. While adults frequently develop acute renal failure (ARF) during episodes of acute decompensated heart failure (ADHF), data has lacked for children. The research done by Dr. Goldstein and his colleagues aimed to determine the incidence and severity of ARF in children with ADHF, and to see if ARF development affects patient outcome.

http://tinyurl.com/8uo5m



Study shows success — and less risk — in treating kids with heart rhythm problems

3-D computer mapping lowers radiation dose in ablation procedure

DALLAS -- A University of Michigan Cardiovascular Center team today is reporting high levels of success, and lowered risk and radiation dose, from a new approach to treating children with rapid heartbeats and other heart rhythm conditions.
In a presentation at the American Heart Association's Scientific Sessions meeting, members of the Michigan Congenital Heart Center will present new data from a study of a treatment called RF catheter ablation in children using a three-dimensional computer assisted navigation system.
They show that by adding the 3-D navigation system to a conventional X-ray based method to visualize electrophysiological catheters inside the heart, they were able to successfully treat 99.1 percent of 113 patients included in the study.
While the procedural success rate was very high, the most significant finding was that the patients who were treated using the 3-D computer navigation system were spared almost half the radiation dose received by 108 comparable patients treated immediately before the new system was available.



New results show the RTS,S malaria vaccine candidate protects children for at least 18 months

GlaxoSmithKline (GSK) Biologicals, the Hospital Clínic of the University of Barcelona, the Manhiça Health Research Centre (CISM), and the PATH Malaria Vaccine Initiative (MVI) today released new data on the duration of efficacy of GSK Biologicals' malaria vaccine candidate, RTS,S/AS02A, in children. A follow-up to the landmark six-month efficacy study results published by The Lancet in 2004, today's findings show that RTS,S/AS02A remained efficacious over an 18-month observation period.
The findings are published in the November 15, 2005 on-line edition of The Lancet and are presented at the Multilateral Initiative on Malaria's Pan-African Malaria Conference in Yaoundé, Cameroon.
CISM conducted the study in partnership with Mozambique's Ministry of Health. Fourteen hundred forty-two children who had received a three-dose regimen of the vaccine in 2003 were followed for continued assessment of safety, immunogenicity, and efficacy. No further malaria vaccinations were given. For the 18-month period of follow-up, RTS,S/AS02A was shown to reduce clinical malaria episodes by 35 percent and severe malaria episodes by 49 percent.



Wheezing prevalence patterns established by age 6

American Thoracic Society journal news tips for November 2005 (second issue)

Among children who exhibit asthma-like symptoms during preschool years, researchers have found that patterns of wheezing prevalence and levels of lung function are established by age 6 and do not significantly change for at least 10 years.
Their findings were reported in the second issue of the November 2005 American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
Fernando D. Martinez, M.D., of the Arizona Respiratory Center, University of Arizona Health Sciences Center, Tucson, along with eight associates, studied 826 children based on the occurrence of "wheezing lower respiratory illnesses" before age 3 and active wheeze at age 6. Among this group, there were 425 "never wheezers," 164 "transient early wheezers," 113 "persistent wheezers," and 124 "late-onset wheezers."



Tuesday, November 15, 2005

Health news Update (from yesterday)

Retired Doctors, Retired Nurses, Very Busy Clinics

By LESLIE BERGER

GREAT BARRINGTON, Mass.

AFTER working for years as a pediatric nurse practitioner here, Lynne Shiels was hardly naïve about the costs of health care but nonetheless thought that everyone in this picturesque area had access to medical help.

This is Berkshire County, after all, a blue place in one of the bluest states, a magnet for music lovers and antiques collectors that seems to have as many government-financed medical programs as it does boarding schools and Colonial-era farms.

But Mrs. Shiels was astonished to learn, once she started helping at a new clinic run by Volunteers in Medicine Berkshires, just how many uninsured residents the county has - not just recent immigrants but native sons and daughters whose medical benefits have vanished as factories have closed, or whose co-payments have become too expensive to carry.

"The biggest thing that's been an eye-opener to me," said Mrs. Shiels, a volunteer nurse at the free clinic, "is that a big part of our patients are not only undocumented workers but people who were insured at one time, lost their insurance, stopped going for any kind of ongoing health care and are coming to us with a variety of problems."

The clinic has been a revelation for nearly everyone involved since it opened less than a year ago.

Dr. Howard Arkans, a deeply tanned pediatrician and insurance company administrator who retired to pamper his grandchildren and play tennis, has been surprised by his own level of commitment, volunteering 20 hours a week or more as medical director. Leonard Simon, a retired bank executive who was among the clinic's founders and serves on its board, has been impressed by the local altruism that supplies a $300,000 yearly operating budget and a spreading circle of doctors, nurses and psychologists giving pro bono care. Estella Bodnar, a daughter of Puerto Rican immigrants who is one of the clinic's three Spanish-language interpreters, has been moved by the changing face of Berkshire County, where the population of 132,000 is thought to include 10,000 Latinos; more than half the clinic's patients so far are Hispanic.

http://tinyurl.com/bwkga


Q&A: 'Cured' of HIV
There have been reports that a British man with HIV has apparently become clear of the virus.
BBC News website looks at the issue.

Q: What is HIV?

HIV infects and gradually destroys the infected person's immune system, reducing their protection against infection and cancers.

The main cell HIV infects is called a T helper lymphocyte. This cell is a crucial part of the immune system, and co-ordinates the actions of other immune system cells.

A big reduction in the number of T helper cells seriously weakens the immune system.

Aids, or Acquired Immune Deficiency Syndrome, is a term that describes the point when a person's immune system can no longer cope because of the damage caused by HIV and they start to get one or more specific illnesses.

Does a negative test mean that HIV isn't present?

No.

There are different tests to check whether someone is likely to be infected with HIV.

One is an antibody test, which checks whether the body has mounted an immune response against the virus.

A positive antibody test usually means that the person is infected with HIV.

Occasionally, however, a person can have a positive antibody test without being infected with HIV - a 'false positive' test.

The reverse is also possible - a negative test result even though the individual has the virus. This is particularly common if the person has only just caught the infection. It may be too early to detect it.

Another type of test, which detects the presence of HIV particles in the blood, can be done.

Dr Deenan Pillay, a virologist at University College London and the Health Protection Agency, said: "No test is perfect. And individual people are different and behave differently to HIV."

http://tinyurl.com/dnank


Max Planck Researchers discover a protein which is deadly for anthrax bacteria

Scientists from the Max Planck Institute for Infection Biology in Berlin discovered why lung, but not skin, anthrax infections are lethal. As reported in the newest issue of PloS Pathogen (November 2005) Neutrophils, a form of white blood cells, play a key role in anthrax infections. They can kill Bacillus anthracis by producing a protein called alpha-defensin. This discovery might now pave the way towards the development of new therapies for the fatal lung form of anthrax.

http://tinyurl.com/cegmp


Preparing for a Pandemic
One day a highly contagious and lethal strain of influenza will sweep across all humanity, claiming millions of lives. It may arrive in months or not for years--but the next pandemic is inevitable. Are we ready?By W. Wayt Gibbs and Christine SoaresWhen the levees collapsed in New Orleans, the faith of Americans in their government's ability to protect them against natural disasters crumbled as well. Michael Chertoff, the secretary of homeland security who led the federal response, called Hurricane Katrina and the flood it spawned an "ultracatastrophe" that "exceeded the foresight of the planners."
But in truth the failure was not a lack of foresight. Federal, state and local authorities had a plan for how governments would respond if a hurricane were to hit New Orleans with 120-mile-per-hour winds, raise a storm surge that overwhelmed levees and water pumps, and strand thousands inside the flooded city. Last year they even practiced it. Yet when Katrina struck, the execution of that plan was abysmal.
The lethargic, poorly coordinated and undersized response raises concerns about how nations would cope with a much larger and more lethal kind of natural disaster that scientists warn will occur, possibly soon: a pandemic of influenza. The threat of a flu pandemic is more ominous, and its parallels to Katrina more apt, than it might first seem. The routine seasonal upsurges of flu and of hurricanes engender a familiarity that easily leads to complacency and inadequate preparations for the "big one" that experts admonish is sure to come.


Exercise good remedy for arthritis pain

By Shannon Russell
Enquirer staff writer

Tom Keuper tried to pick a dime off the floor and regretted being idle for a year.

The Union resident's back and joints ached as he stooped over months ago. He wasn't surprised when his doctor later said discs were degenerating in his back - it's "part of getting old," the 72-year-old said - or that he had arthritis in his lower back.

But he was surprised to hear part of the prescription: exercise.

"I'd worked out my whole life except for last year. I got lazy and started to gain weight," Keuper said. "My doctor suggested I work out, and I thought it might help my back pain."

Did it ever. Keuper has been exercising at Sports of All Sorts recreation center three times a week on strength-building machines and on a treadmill. Not long after starting a fitness regimen, his back pain disappeared.

http://tinyurl.com/8fhls


Is green tea a miracle drink?
By Kathie Sutin
SPECIAL TO THE POST-DISPATCH
11/14/2005
To hear the hype, you might think it's the Holy Grail of the quest for health.
The list of the purported benefits of this drink goes on and on. It's been said 
to:
* Prevent cancer or help fight it
* Stave off heart attacks
* Reduce cholesterol
* Prevent dental cavities and promote gum health
* Enhance memory
* Protect the skin from ultraviolet rays
* Reduce the inflammation of arthritis
* Help with weight loss
* Increase mental alertness
* Improve airflow to the lungs therefore alleviating asthma
* Increase fertility in women
So what is this behemoth of beverages?
It's green tea, a drink relatively new to the American palate but one the 
Chinese have been enjoying for more than 5,000 years ago.
The problem is despite all the great press green tea has received in recent 
years, can we be sure it really does half of what its proponents claim?
No one can say for sure


Fentanyl patch safe and effective alternative to oral opioids for pediatric pain patients

A new study says using a transdermal patch to deliver the opioid fentanyl is an effective way to control pain in children. Results from an international study published in the December 15, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, indicate that the fentanyl patch is safe for children aged 2 to 16 years.

http://tinyurl.com/bybyy


Parental discipline, life events, and peers affect teens' risk of depression

How parents treat their adolescent children, including the way they discipline them, as well as the kind of life events and social interactions teenagers experience, can affect an adolescent's risk of depression, regardless of any genetic predisposition towards the mental illness.

These findings from researchers at King's College in London, published in the November/December issue of the journal Child Development, suggest that the environment in which teenagers find themselves has an impact on their risk of depression independent of their genetic background, which is already known to be a strong predictor of depression.


Prevent risky behavior in your teen: Get to know their friends in and out of school

If you've ever watched a group of elementary school kids interact, you can quickly see there's usually a "problem child," one whose behaviors are aggressive or disruptive for peers and teachers. For years, researchers have known that these "antisocial" children are often rejected by their peers. But now a new study published in the November/December issue of the journal Child Development finds that as these antisocial children move into adolescence, they begin to form alliances with other antisocial kids, increasing the chance they'll participate in risky behavior in their teenaged years.
To reach these conclusions, researchers from the University of Padova in Italy surveyed 577 sixth through eighth graders and their teachers in three middle schools in Milan, Italy about antisocial behavior and peer relations.


Kids can remember events even if they can't remember times

Finding has significant implications for child testimony

Remembering when an event occurred is particularly important when you're a witness in the legal system. But while adults are pretty good at determining the time of an event based on reconstructing that event (i.e., if the event occurred at the beach, it must have been summer), a new study finds that isn't the case for children.
The study, published in the November/December issue of the journal Child Development, finds that while children aged 4 through 13 can recall the details of an event fairly well, they are unable to extrapolate further and link those details with a specific time of year, even when it occurs around a major holiday. Researchers from Oberlin College in Ohio and the University of Southern California in Los Angeles gave a group of 86 children ranging in age from 4 to 13 two, in-class demonstrations shortly before or after Halloween. Three months later, they asked the children to recall the content of the demonstrations and when they occurred.
Regardless of their age, the children had difficulty remembering that Halloween was near one of the target events. They were also unable to remember whether the target event occurred before or after the holiday, regardless of how well they recalled the event's details.


One reason to test premature babies early: Results provide clues to later cognitive development

The rate of premature births in the United States is on the rise, with one in eight babies born before 37 weeks gestation in 2003, a 13 percent increase from 10 years ago. While it's long been known that premature birth increases a child's risk of learning and other cognitive disabilities, including lower IQ, language delay, poorer school achievement and learning disabilities, it has not been known if those problems are linked to cognitive development in early infancy.
Now a study from researchers at the Albert Einstein College of Medicine in the Bronx, N.Y., and the University of Ghent in Belgium, finds that early cognitive deficits in infancy such as poorer attention, slower processing speed and poorer recognition memory are important harbingers of later cognitive deficits, fully accounting for lower cognitive scores of 2- and 3-year-olds. The study was published in the November/December issue of the journal Child Development.


Mayo researchers lead team that discovers role of dendritic cells in childhood autoimmune disease

Provides new strategy for designing better treatments

ROCHESTER, Minn. -- Mayo Clinic researchers, working with colleagues at the University of Minnesota and University of Pittsburgh, are the first to describe a new role for a specialized cell of the immune system in children suffering from a rare muscle-damaging disease known as juvenile dermatomyositis (JDM). The specialized cells, called dendritic cells, have never before been found inside muscle tissue of JDM patients -- a discovery that suggests they are tightly linked to initiation of the disease process. The finding opens new possibilities for designing better treatments for JDM, and possibly for other related diseases such as multiple sclerosis, rheumatoid arthritis and lupus.


Ketogenic diet prevents seizures by enhancing brain energy production, increasing neuron stability

WASHINGTON, D.C. -- Although the high-fat, calorie-restricted ketogenic diet (KD) has long been used to prevent childhood epileptic seizures that are unresponsive to drugs, physicians have not really understood exactly why the diet works. New studies by a research team at Emory University School of Medicine show that the diet alters genes involved in energy metabolism in the brain, which in turn helps stabilize the function of neurons exposed to the challenges of epileptic seizures. This knowledge could help scientists identify specific molecular or genetic targets and lead to more effective drug treatments for epilepsy and brain damage.
The research will be presented at the annual meeting of the Society for Neuroscience in Washington, D.C. by Kristopher Bough, PhD, a postdoctoral student in the laboratory of Emory pharmacology professor Raymond Dingledine, PhD.
"These findings support our hypothesis that a dietary regimen can dramatically affect the expression of genes and the function of neurons within the brain, which enhances the ability of these neurons to withstand the metabolic challenges of epileptic seizures," Dr. Dingledine said.

New RSV treatment for at-risk infants under study

Toni Baker
Nov. 11, 2005

A new, enhanced-potency monoclonal antibody designed to keep the sniffles from turning into a devasting illness in at-risk babies is under study at the Medical College of Georgia Children’s Medical Center.

The international study compares MEDI-493, a monoclonal antibody already approved by the U.S. Food and Drug Administration to treat respiratory synctial virus, or RSV, to the more potent MEDI-524, says Dr. Jatinder Bhatia, chief of the MCG Section of Neonatology and a principal investigator.

http://tinyurl.com/cavoc



New 'eye movement' test may help treat fetal alcohol syndrome

Tool is more objective, accurate in identifying children affected by

KINGSTON, Ont. – A simple test that measures eye movement may help to identify children with Fetal Alcohol Spectrum Disorder (FASD) and ultimately lead to improved treatment for the condition, say Queen's University researchers.

At present there are no objective diagnostic tools that can be used to distinguish between children with FASD – which affects approximately one per cent of children in Canada – and those with other developmental disorders such as Attention-Deficit Hyperactivity Disorder (ADHD).

Researcher James Reynolds and graduate student Courtney Green, of the Department of Pharmacology and Toxicology and the Centre for Neuroscience Studies, will present their findings next week at the annual meeting of the international Society for Neuroscience in Washington, D.C.

http://tinyurl.com/bhh48