Wednesday, October 17, 2007

Smaller Class Size Might Just Be The Key

Public release date: 16-Oct-2007

Contact: stephanie berger
212-305-4372

Study shows reducing class size may be more cost-effective than most medical interventions


October 16, 2007 -- Reducing the number of students per classroom in U.S. primary schools may be more cost-effective than most public health and medical interventions, according to a study by researchers at Columbia University Mailman School of Public Health and the Virginia Commonwealth University. The study indicates that class-size reductions would generate more quality-adjusted life-year gains per dollar invested than the majority of medical interventions. The findings will be published in the November issue of the American Journal of Public Health.

The researchers estimated the health and economic effects of reducing class sizes from 22–25 students to 13–17 students in kindergarten through grade 3 nationwide, based on an intervention tested in Project STAR (Student Teacher Achievement Ratio), a large multi-school randomized trial that began in 1985. Project STAR is considered the highest quality long-term experiment to date in the field of education.

The study shows that a student graduating from high school after attending smaller-sized classes gains an average of 1.7 quality-adjusted life-years and generates a net $168,431 in lifetime revenue. "Higher earnings and better job quality enhance access to health insurance coverage, reduce exposure to hazardous work conditions, and provide individuals and families with the necessary resources to move out of unfavorable neighborhoods and to purchase goods and services," says Peter A. Muennig, MD, MPH, assistant professor of Health Policy and Management at the Mailman School. "Regardless of class size, the net effect of graduating from high school is roughly equivalent to taking 20 years of bad health off of your life."

When targeted to low-income students, the estimated savings would increase to $196,000 per additional graduate. "This is because low-income students seem to benefit more from the additional attention afforded by small classes," noted Dr. Muennig. "Because we focused on a relatively expensive intervention and examined outcomes over a range of values, our results should provide a conservative framework for evaluating this and other interventions as long-term data on educational interventions become more plentiful," he commented.

The performance of students in the U.S. has been declining relative to the performance of students in other countries. With health costs soaring and student performance falling, the United States is in jeopardy of losing its economic dominance.

The findings not only raise issues of whether investments in social determinants of health can be more cost-effective than investments in conventional medical care, "but more intriguing still, also bring up the idea that each dollar invested in education could also potentially produce other long-term returns," observes Dr. Muennig. He notes that further analysis will refine models and produce more-precise estimates, but "these findings do point to the importance of looking more broadly at the options available for improving health outcomes—including those outside the boundaries of clinical medicine."


http://tinyurl.com/2s7lqt

Tuesday, October 09, 2007

Top Ten Inventions of 2007

um....the year aint over.... oh well.


R&D Magazine has sponsored the "Oscars of Inventions" for 45 years. These research and design awards are coveted by government as well as private industry inventors. The 100 winners selected by R&D Magazine for 2007 are stunning innovations - resourceful, effective, inspiring. A significant portion of the 2007 awards are homeland security/military innovations; others are environmental, health, and there's even innovations for kids, like a must-have-Holiday-toy robot!





My favorite so far:
2. No More Blood Tests!
 



Electro Needle Biomedical Sensor Array



Some of the 2007 awards have gone to inventions that seem just short of miraculous and the Electro Needle Biomedical Sensor Array comes close. This is a small patch device with electro-chemically treated probes. When the patch is applied to the skin, it has the ability to ascertain chemical readings present in a patient's blood without having to withdraw any blood. Thus, readings such as "carbohydrates, electrolytes, lipids, enzymes, toxins, proteins, viruses, and can be detected in a patient's blood or interstitial cellular fluid." No more for "good" veins? You mean no more vials and vials and vials taken? One great step for medicine; 15 great steps for the sick folks in the emergency room. Developed by the Sandia National Laboratories.

Wednesday, August 29, 2007

Toy Safety

Make sure your kids toys are safe by visiting SaferToys

Posted Aug 20th 2007 10:00AM by Chris Gilmer
Filed under:
Fun, Internet, Blogging, Web services, web 2.0


With all the news recently about the giant fiasco concerning toys being created using lead contents, there is no better time to ensure your child's safety. Many parties can have fingers pointed at them in this matter, but let's forget about who is to blame for a second and just make sure that the toys our children are playing with are safe.

SaferToys is a digg like social news site that lists out all stories relating to the safety, recalls, and news on the latest unsafe toys. It's an easy place for concerned parents to check in with and track the latest unsafe toys. Stories can be submitted and voted on so they rise to the top of the news list. Users can also share their insights via comments on each story submitted.

SaferToys uses the Pligg platform, an open source social content management system that lets users submit, vote and comment on stories.

Useful Health Monitoring Hack

pervasive health monitor (got granny?)

posted aug 22nd 2007 11:05pm by will o'brien
filed under: misc hacks

Monday, August 20, 2007

Children and lead

Lead in Chinese products more widespread than just toys.   In continuing coverage from yesterday's briefing, the AP (8/16) reports, "China's problems with lead in consumer products go far beyond tainted toys. From playthings to paint to gasoline, Chinese companies use lead in a wide range of products and experts say China's children are suffering the health consequences." While the CDC estimates that only "about 310,000 U.S. children ages 1 to 5 have blood lead levels that require treatment or other measures," research say "up to one-fifth of Chinese children tested had unsafe levels in their blood."
      In a separate article, the AP (8/16) adds, "Some vinyl baby bibs made in China and sold at Toys 'R' Us stores contain lead levels well above federal safety limits for lead in paint," a California environmental group said Wednesday. "A bib with 'Winnie the Pooh' characters and store-brand bibs sold under the Koala Baby and Especially for Baby labels all tested positive for lead in concentrations three to four times what the Environmental Protection Agency allows in paint," according to the Center for Environmental Health in Oakland. The AP notes that the group "bought the four bibs at San Francisco Bay-area Toys 'R' Us and Babies 'R' Stores and contracted with a private lab that specializes in product safety to perform the tests." When notified of these results, "A Toys 'R' Us spokeswoman said tests performed in May by a lab contracted by the company found that the bibs met not just federal standards but California's more stringent limits on lead content. But more bibs were being pulled from the shelves Wednesday for further testing."

Monday, August 13, 2007

Remove tonsils, improve sleep, get better grades (For Beth)

Tonsil Removal May Cure ADHD Behavior in Kids

from the Dallas Morning News

TUCSON, Ariz. - Little T.J. was a monster. There's no other way to
say it.
Extremely hyperactive, the toddler ran around in circles, destroying
everything in his path. He got kicked out of day care and banned from
friends' homes...Friends told his family that T.J. - short for Terence
Johnson — was destined to be "the next serial killer."

...That was then. Today, as T.J. gets ready to turn 3, he is a
changed boy.
Lively, to be sure, but affectionate instead of mean. "It's a total
turnaround - this is a different child," Ms. Norton said. "Everybody
notices the difference."

A frontal lobotomy? Electroshock therapy? Powerful drugs? No, T.J.
had his
tonsils out. The removal of a child's tonsils can, in some cases,
significantly improve, even cure, severe hyperactivity often
diagnosed as
attention deficit hyperactivity disorder.

To read more:
http://www.dallasnews.com/sharedcontent/dws/news/healthscience/

stories/081207dnnattonsils.26239902.html

Or: http://tinyurl.com/2zs23h

fixing a hole in the heart: for Debbie

Hole-in-the-Heart Self Repair Kit

from BBC News Online

Experts have found a way to employ the body's natural healing power to
treat a common heart defect linked with stroke and migraine.

One in four people has a valve-like hole in the heart, known as a patent
foramen ovale (PFO). The defect can be closed surgically using a
graft, but
this can cause damage to surrounding tissue.

A team at London's Royal Brompton Hospital has used a "bioabsorbable"
patch
to solve the problem. The patch acts as a temporary plug until the body
replaces it with healthy normal tissue, usually within 30 days. PFO, an
opening in the wall between the two upper chambers of the heart, usually
produces no symptoms, but in some people it significantly increases the
risk of stroke and migraine.

To read more: http://news.bbc.co.uk/2/hi/health/6940085.stm

Or:

http://tinyurl.com/yrloch

Tuesday, August 07, 2007

I love coffee

Coffee May Protect Women's Memory, Study Says
Caffeine May Boost Memory for Older Women, Study Suggests

Thursday, June 28, 2007

Gaming addiction being taken seriously!

More Study Needed on Gaming Addiction

from the Baltimore Sun

The American Medical Association warned the public yesterday about the
potential dangers of video-game addiction, but rejected a call from a
Maryland physicians group and other doctors to declare the condition a
formal medical disorder.

Instead, the national doctors' group urged more formal research into the
impact of video game use and called for a review of the video game
ratings
system.

We would like to find out exactly what this is, what it does, its
harms and
even its benefits," said Dr. Martin Wasserman, executive director of
MedChi, the Maryland State Medical Association. MedChi helped bring the
issue before the AMA's annual conference in Chicago this week...

To read more: http://www.baltimoresun.com/news/health/bal-

to.hs.video28jun28,0,1618988.story

Or: http://tinyurl.com/2qydxw

Amazing report on brain research at MIT

This one blows my mind. I remember the story, it struck a deep cord
in me when I first read it at age ten.
To have anything like it (though the comparison is one that does not
stand up to strenuous scrutiny) is a bit frightening.
I hope, with all my heart, that this research turns into something
wonderful for anyone born with this problem, and for their families
as well.


Scientists Reverse Mental Retardation in Mice

from Scientific American

In a case of life imitating art, researchers at the Massachusetts
Institute
of Technology (M.I.T.) reported today that they had successfully
reversed
mental retardation in mice, just as scientists did in the classic 1966
novel Flowers for Algernon.

In the book by Daniel Keyes, scientists use experimental surgery - first
tested on a mouse named Algernon - to dramatically boost the
intelligence
of a mentally retarded janitor named Charlie Gordon.

Now M.I.T. scientists report in Proceedings of the National Academy
of the
Sciences USA that they ameliorated brain damage in mice caused by a
genetic
disorder known as fragile X syndrome by blocking an enzyme involved in
cellular development.

To read more: http://www.sciam.com/article.cfm?articleID=6901F70B-

E7F2-99DF-3648F0789D1EC063&chanID=sa003

Or: http://tinyurl.com/2e6kwx

Thursday, June 21, 2007

Blood Test For Colon Cancer

Blood test can reveal cancer of colon
Hopkins study finds procedure is nearly colonoscopy's equal
By Chris Emery
SUN REPORTER
Originally published June 20, 2007
Johns Hopkins researchers are developing a simple blood test that can help doctors determine who needs a colonoscopy, a screening procedure for colon cancer recommended for all adults over 50 - but one considered so unpleasant that many avoid it.
The new test, which looks for cancer-related proteins in the blood, identifies colon cancer and precancerous polyps almost as well as a colonoscopy, according to a study published in the journal Cancer Research.
The authors say their test won't replace colonoscopies but might provide a noninvasive means of identifying high-risk patients - and an incentive for them to undergo the more invasive procedure.

Hope for Various Brain Diseases

Research brings hope of curing brain disease


Ian Sample, science correspondent
Monday June 18, 2007

Scientists have developed a revolutionary new treatment for neurological diseases that uses an injection to tweak the way genes work in the brain.
The research raises hopes for a new era of effective treatments for some of the most debilitating - and so far incurable - brain conditions, including cancer and Alzheimer's disease.
Tests of the therapy at Harvard Medical School in Boston found that a simple injection was able to cure mice of a potentially fatal brain disease. The researchers behind the breakthrough are planning further tests and expect to conduct human trials within five years.
The team used a powerful new technique called RNA interference to silence faulty genes or viruses that cause brain diseases. The principle of gene silencing is simple: scientists build tiny strands of the genetic material called RNA which, when injected into cells, latch on to problematic genes and smother them, effectively shutting them down.

Tuesday, May 29, 2007

Beware Excess Suppliments

This is not the first study to find this:



Studies Examine Prostate Cancer-Nutrition Links 



By DELTHIA RICKS
Newsday

May 29 2007

Two large, unrelated studies recently renewed the focus on prostate health and nutrition, raising questions about vitamin supplements and a pigmented compound in tomatoes that colors the fruit red.

How safe are multivitamins?

Does lycopene, which is added to many vitamin supplements aimed at men, actually protect them from prostate cancer?

Researchers at the National Cancer Institute found that men who took more than one multivitamin daily had a 32 percent increased risk of advanced prostate cancer with a fatal outcome, nearly double the risk of men who did not take the pills.

But Dr. Michael Leitzmann, an institute investigator and author of the analysis, says the study is not a condemnation of multivitamins.

"Men should not stop taking multivitamins," he says. "It was only the men who were taking multivitamins in excessive doses where we saw an increase in risk."

The study was published in the Journal of the National Cancer Institute.

Leitzmann and his colleagues studied 300,000 men in a six-year period who had filled out questionnaires about vitamin use. Taking more than seven multivitamin tablets per week was associated with advanced prostate cancer. Curiously, excessive vitamin intake was not a factor in early-stage tumors. Exactly how the pills could be associated with advanced disease remains unanswered.

European cancer experts writing in an accompanying editorial said the study questions "the beneficial value of antioxidant vitamin pills in generally well-nourished populations." In an even more sobering assessment of the data, the editorialists noted that "antioxidant supplements could have unintended consequences for our health."

Dr. Iris Granek, an associate professor of clinical medicine at Stony Brook University Medical Center, says the basic take-home message is not to exceed the recommended dosage of multivitamins. There are many variables, she says, in how vitamins are metabolized from one person to the next.

Still, a study by the American Cancer Society demonstrated two years ago that the death rate from prostate cancer was marginally higher in men who took multivitamins compared with those who avoided the pills. That research involved 500,000 men and the findings set the scientific community astir. But scientists have not given up on vitamins.

Granek is principal investigator of Long Island's contribution to an ongoing 12-year federal study examining whether vitamin E or the mineral selenium prevent the disease. The two supplements had shown in smaller studies in the 1990s that men were protected from prostate cancer. Government health officials six years ago embarked on the larger study to find more definite answers.

Yet much of the old wisdom seems to be falling by the wayside. NCI scientists and those at the Fred Hutchinson Cancer Research Center in Seattle found that lycopene apparently does not prevent prostate cancer. "Our study adds an important piece to the puzzle," says Dr. Ulrike Peters, lead author of the study. "It's disappointing, because lycopene might have offered a simple way to lower risk."

Supplement manufacturers are not abandoning lycopene. Bayer, which makes a vitamin supplement aimed at boosting prostate health, plans to continue adding lycopene to the product, according to a company spokesman.

Copyright © 2007, Newsday, Inc.

http://tinyurl.com/ys6ss7



Innovative device to treat brain cancer shows promise in early studies

First post in a LONG time:

2 out of ten patients remained progression free more than 2 years after treatment initiation

Haifa, Israel – May 29, 2007 – New early data showed that an investigational device that specifically targets rapidly growing cancer cells with intermediate frequency electrical fields -- called Tumor-Treating Fields (TTFields) -- more than doubled the median overall survival rates in patients with recurrent glioblastoma multiforme (GBM), the most common and aggressive type of malignant brain tumor. These survival rates observed in the data were compared to historical data. This research, which includes the results of cell culture, animal and early phase human trials, appears in the current issue of the Proceedings of the National Academy of Sciences (PNAS).

The device, called the Novo-TTF, uses electrical fields to disrupt tumor growth by interfering with cell division of cancerous cells, causing them to stop proliferating and die off instead of dividing and growing. Healthy brain cells rarely divide and have different electrical properties than cancerous brain cells. This allows the device to target cancer cells without affecting the healthy cells.

At the time of publication, researchers found that among the 10 patients with recurring GBM treated with the Novo-TTF, the median length of time to disease progression was 26.1 weeks; progression free survival at six months was 50 percent; and median overall survival was 62.2 weeks. This is more than double the rates reported in historical data – approximately 9.5 weeks, 15.3%, and 29.3 weeks, respectively.

"The novel mechanism of action of the Novo-TTF relies on the physical properties of the cancer cells, their shape and size, rather than the chemical make-up. We believe that this distinction enables the device to stop local proliferation and metastasis of cancer, which would explain the efficacy observed in these early findings," said Dr. Elion Kirson lead author and Vice President of Research and Development, NovoCure. "Based on our preliminary research, we believe that there is a high probability that TTFields may prove to be an effective and safe approach to treating a large number of human cancers."


###

Based on these positive early findings, patient enrollment has begun for a large-scale phase III clinical trial to further clarify the efficacy and safety of the Novo-TTF in the treatment of recurrent GBM. The research is being conducted at 12 leading cancer centers across the United States, and eight centers in Europe. More information on the trial can be found at www.novocuretrial.com or by calling 800-978-0265.

STUDY DETAILS

The single-arm, pilot trial of the safety and efficacy of Novo-TTF treatment was performed on 10 patients for a total of 280 weeks. Efficacy analysis was performed for 10 recurrent GBM patients by comparing time to tumor progression (TTP), progression-free survival (PFS) at 6 months and overall survival (OS) in recurrent GBM patients to these endpoints in historical data.

An unfavorable side effect profile is a major limitation of all current cancer treatments. The ten patients involved in this study received treatment for a total of 280 weeks without a single treatment related adverse event. The only device related side effect seen was a mild to moderate contact dermatitis beneath the field delivering electrodes, which responded well to the application of topical cream and periodic electrode relocation.

ABOUT NOVO-TTF

The Novo-TTF is a non-invasive medical device developed by NovoCure Ltd. that is currently being evaluated in a Phase III clinical trial for the treatment of recurrent glioblastoma multiforme (GBM). The device disrupts the division of cancer cells in the brain using alternating electrical fields delivered by means of insulated electrodes applied to the surface of the scalp. The electrodes look like bandages with wires attached. The device is powered by a small lightweight battery pack. Patients carry the Novo-TTF device in a specialized over-the-shoulder bag and receive continuous treatment without changing their daily routine.

ABOUT NOVOCURE

NovoCure Ltd. is a private company dedicated to developing innovative cancer treatments. Professor Yoram Palti, M.D., Ph.D., founded NovoCure in 2000 to develop his research in treating cancer with electrical fields. In addition to Professor Palti, NovoCure has assembled a world class team of experts who have spent their entire careers inventing, building, or commercializing innovative medical products. Please visit our website to see the biographies for NovoCure's team (www.novocuretrial.com/about.html).


http://tinyurl.com/2up5kg